Abstract: Characteristics and Prognosis of 127 Cases with Bronchopulmonary Neuroendocrine TumorsCheng CHEN1, Cuicui ZHANG2, Na LI2, Ziliang JIN2, Kai LI2Correspondence to: Kai LI, E-mail: likai5@medmail.com.cnDepartment of Pulmonary Medical Oncology, Cancer Institute and Hospital of Tianjin Medical University, Tianjin 300060,ChinaAbstract Objective: Bronchopulmonary neuroendocrine tumor (BNT) includes typical carcinoid (TC), atypical carci-noid (AC), large-cell neuroendocrine carcinoma (LCNEC) and small-cell lung carcinoma (SCLC). Although sharing featuresof cytohistology and immunohistochemistry, the clinical characteristics and prognosis of these tumors vary greatly. The aimof our study was to elucidate clinicopathologic characteristics of BNT and to analyze its prognostic factors. Methods: Theclinical data of 127 patients with BNT admitted to our hospital between April 1975 and July 2009 were enrolled in the retro-spective analysis. The prognostic factors considered in the univariate and multivariate analysis included sex, age, smokinghistory, family history, histological type, TNM stage and treatment. Results: The overall 1-, 3- and 5-year survival rates forpatients with BNT were 80.2%, 46.9% and 40.6%, respectively; the 5-year survival rates for patients with TC, AC , SCLCand LCNEC were 79.3%, 41.8%, 11.4% and 0, respectively. Cox univariate analysis revealed that the tumor size ( P =0.000), histological type ( P = 0.000), TNM stage ( P = 0.000) were postoperative adjuvant radiotherapy and/or chemothera-py ( P = 0.000) were prognostic factors after surgery. Cox multivariate analysis showed that TNM stage ( P = 0.040) werepostoperative adjuvant radiotherapy and/or chemotherapy ( P = 0.032) were independent prognostic factors. Conclusion:Radical surgery remains the major therapeutic protocol for treatment of BNT. TNM staging and postoperative adjuvant ra-dio-chemotherapy are independent prognostic factors for BNTs.Keywords Bronchopulmonary neuroendocrine tumor; Clinical characteristics; Prognostic factor